⮝ Full datasets listing
PXD070556
PXD070556 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dataset for 3,3'-Dichlorobiphenyl (PCB 11) Alters the Hepatic Expression of Cytochrome P450 Enzymes in the Liver of Mouse Dams Exposed Orally During Pregnancy and Lactation |
| Description | As part of a larger study on neurodevelopmental effects of lower chlorinated PCB 11, we characterized PCB 11 distribution in postweaning mouse dams orally developmentally exposed to PCB 11 via the diet. We used and liquid chromatography tandem mass spectrometry (LC MS/MS) based proteomics to map changes in hepatic protein levels following PCB 11 exposure, gas chromatography tandem mass spectrometry (GC MS/MS) to quantify PCB 11 and its metabolites in brain, liver, and serum; and liquid chromatograph-high resolution mass spectrometry (LC HRMS) to screen serum for additional PCB 11 metabolites. The accompanying dataset contains raw and processed files from the proteomic analysis only, including protein identification from AMICA, and network interaction data from STRING. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-11-10 |
| AnnouncementXML | Submission_2025-11-10_16:03:13.757.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Hans-Joachim Lehmler |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; unknown modification; Oxidation |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-10 11:56:08 | ID requested | |
| ⏵ 1 | 2025-11-10 16:03:14 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: PND21, liver, PCB 11, polychlorinated biphenyl (PCB), TMT16-plex, dams, mice, DatasetType:Proteomics |
Contact List
| Hans-joachim Lehmler | |
|---|---|
| contact affiliation | The University of Iowa |
| contact email | hans-joachim-lehmler@uiowa.edu |
| lab head | |
| Hans-Joachim Lehmler | |
| contact affiliation | University of Iowa |
| contact email | hans-joachim-lehmler@uiowa.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099827/ |
