PXD070517

PXD070517 is an original dataset announced via ProteomeXchange.

Title	PCT-assisted DIA Proteomics Unveils Molecular Changes in Kidney Tissues of Patients with Minor Glomerular Abnormalities
Description	Our study pioneers a systematic comparison of DNT and MGA proteomes using cutting-edge analytical workflows. Freshly obtained kidney tissues (acquired via puncture or surgery) underwent pressure cycling technology (PCT)-assisted lysis15, 16. The extracted proteins then underwent proteolysis using a modified filter-aided sample preparation (FASP) and data independent acquisition (DIA) MS. This approach not only establishes rigorous methodological benchmarks for control selection but also maps MGA-specific protein networks, potentially revealing actionable biomarkers or therapeutic targets. By integrating advanced proteomic technologies with clinical nephrology, this work may redefine diagnostic paradigms and therapeutic strategies for MGAs.
HostingRepository	iProX
AnnounceDate	2025-11-10
AnnouncementXML	Submission_2025-11-09_23:54:07.478.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	deaminated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-09 23:53:47	ID requested
⏵ 1	2025-11-09 23:54:08	announced

Dataset with its publication pending

submitter keyword: kidney tissue, minor glomerular abnormality, distant non-neoplastic tissue, proteomics, pressure cycling technology, LC-MS/MS

Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
lab head
Yong Zhang
contact affiliation	West China Hospital, Sichuan University
contact email	nankai1989@foxmail.com
dataset submitter

iProX dataset URI