⮝ Full datasets listing
PXD070503
PXD070503 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Global profiling of post-translationally modified crustacean neuropeptidome trends affiliated with feeding activity |
| Description | Neuropeptides modulate a diverse range of physiological functions, such as those associated with feeding. Post-translational modifications (PTMs) are responsible for much of the dynamic nature of neuropeptide isoforms for varied influence on these functions. Mass spectrometry is the gold standard analytical technique for peptidomic analyses, followed by computational methods for peptide identification. However, the computational search space quickly becomes difficult to manage as more modifications are considered. With innovative approaches to endless combinations of potential modifications, such as the PEAKS PTM, we globally profiled the Cancer borealis (Jonah crab) neuropeptidome to investigate the role of PTMs in feeding and appetite related processes across time. Through deep examination of several notable modifications, we were able to propose PTM-associated motifs for neuropeptides, which can bolster future identification abilities. Furthermore, this work revealed neuropeptides which were characteristically modified depending on the crab feeding status and the time post-feeding, pointing to potential biological significance. This is the first large-scale investigation of the modified crustacean neuropeptidome, revealing new insights on the implications of modifications in biological regulation. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-02-16 |
| AnnouncementXML | Submission_2026-02-16_08:58:07.105.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lauren Fields |
| SpeciesList | scientific name: Cancer borealis; common name: Jonah crab; NCBI TaxID: 39395; |
| ModificationList | Amidated |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-11-09 13:20:58 | ID requested | |
| ⏵ 1 | 2026-02-16 08:58:07 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Neuropeptides, Post translational modifications, DatasetType:Proteomics |
Contact List
| Lingjun Li | |
|---|---|
| contact affiliation | University of Wisconsin-Madison |
| contact email | lingjun.li@wisc.edu |
| lab head | |
| Lauren Fields | |
| contact affiliation | UW Madison |
| contact email | lawashburn@wisc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099803/ |
