PXD070470

PXD070470 is an original dataset announced via ProteomeXchange.

Title	Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells
Description	Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. T cells fine-tune their sensitivity to and consumption of IL2 by regulating surface expression and composition of the IL2 receptor. Following antigen recognition, IL2 receptor signaling is polarized towards the immunological synapse. However, how IL2 function is integrated during earlier antigen-dependent T cell synapses is unknown. Here, we demonstrate a synergistic effect between the T cell receptor (TCR) and IL2 receptor signaling at the immunological synapse of CD8+ T cells. TCR and IL2 signaling overlapped in space and time, potentiating each other when simultaneously triggered. Immuno-STATs, a novel class of immunotherapeutics currently in clinical testing, fuse IL2 and peptide-major histocompatibility complex (pMHC) in a single molecule and generate immunological synapses synergistically enhancing both TCR and IL2R signaling to effectively expand antigen-specific CD8+ T cells.
HostingRepository	PRIDE
AnnounceDate	2026-07-06
AnnouncementXML	Submission_2026-07-06_03:14:43.634.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	iolanda Vendrell
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-07 13:14:57	ID requested
⏵ 1	2026-07-06 03:14:44	announced

Dataset with its publication pending

submitter keyword: T cell, Q Exactive,Interleukin, extracellular vesicles

Roman Fischer
contact affiliation	Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
contact email	roman.fischer@ndm.ox.ac.uk
lab head
iolanda Vendrell
contact affiliation	Target Discovery Institute, NDMRB
contact email	iolanda.vendrell@ndm.ox.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD070470
     1. Label: PRIDE project
     2. Name: Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells