PXD070358 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chios Mastic Gum Extract Enhances Antioxidant Defense in Zebrafish |
| Description | Chios mastic gum (CMG), derived from the resin of the Pistacia lentiscus has long been considered a natural remedy in the Mediterranean region. Its anti-inflammatory and an-tioxidant properties have garnered increasing attention from scientists and consumers over recent decades. While substantial evidence supports CMG's efficacy in preventing and treating common health disorders and its potential as a cancer cell inhibitor, the un-derlying molecular mechanisms remain poorly understood. In this study, we utilized zebrafish embryos as a model organism to investigate the molecular pathways affected by CMG administration. Embryos were exposed to non-toxic CMG concentrations for 3 to 96 hours post-fertilization. LC-HRMS proteomics, combined with enrichment analysis, re-vealed key biological pathways, exemplified by oxidative phosphorylation (OxPhos), elec-tron transport chain (ETC), and tricarboxylic acid cycle (TCA). The latter highlights the benefits of CMG administration in energy generation and cytoskeletal integrity. From the plethora of identified proteins, hierarchical clustering revealed three main antioxidant proteins as upregulated, namely copper-zinc superoxide dismutase, thioredoxin-disulfide reductase, and catalase, confirming the contribution of CMG to the enhancement of zebrafish's antioxidant defense. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-22 |
| AnnouncementXML | Submission_2025-12-21_18:43:56.440.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Martina Samiotaki |
| SpeciesList | scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: NEWT:7955; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-11-05 06:59:54 | ID requested | |
| ⏵ 1 | 2025-12-21 18:43:57 | announced | |
Publication List
| Anastasiadou P, Samiotaki M, Margaritopoulou T, Machera K, Kasiotis KM, Chios Mastic Gum Extract Enhances Antioxidant Defense in Zebrafish. Int J Mol Sci, 26(23):(2025) [pubmed] |
| 10.3390/ijms262311338; |
Keyword List
| submitter keyword: Chios mastic gum |
| zebrafish |
| proteomics |
| copper-zinc superoxide dismutase |
| thioredox-in-disulfide reductase |
| catalase |
Contact List
| Konstantinos Kasiotis |
|---|
| contact affiliation | Benaki Phytopathological Institute, 8 Stefanou Delta Str., 14561 Athens, Greece. |
| contact email | K.Kasiotis@bpi.gr |
| lab head | |
| Martina Samiotaki |
|---|
| contact affiliation | Protein Analysis Laboratory
B.S.R.C. "Alexander Fleming",
Alexander Fleming Street 34
16672, Vari,
Greece |
| contact email | samiotaki@fleming.gr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD070358
- Label: PRIDE project
- Name: Chios Mastic Gum Extract Enhances Antioxidant Defense in Zebrafish
