PXD070327

PXD070327 is an original dataset announced via ProteomeXchange.

Title	Shigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation
Description	We demonstrate that OspC effectors enable S. flexneri to evade septin cage entrapment. Mechanistically, OspC catalyzes ADP-riboxanation of SEPT9 at Arg561, a critical site essential for stabilizing septin hetero-oligomers. Notably, ADP-riboxanation or mutation of Arg561 impairs septin polymerization and hence the assembly of higher-order structures, including filaments and cage-like structures. Finally, we provide evidence that S. flexneri OspC effectors act synergistically with OspG to antagonize septin cage entrapment via two distinct post-translational modifications.
HostingRepository	iProX
AnnounceDate	2025-11-04
AnnouncementXML	Submission_2026-03-04_22:58:51.933.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhiheng Tang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ; LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-04 17:42:41	ID requested
1	2025-11-04 17:43:15	announced
⏵ 2	2026-03-04 22:58:52	announced	2026-03-05: Add info.

Tang Z, Xian W, Ö, zbaykal G, ü, ler G, Zhang H, Wang Y, Zhan N, Liu H, You F, Zou Q, Mostowy S, Liu X, Shigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation. Nat Commun, 17(1):1727(2026) [pubmed]

submitter keyword: ADP-ribosylome, IP-MS, SEPT9, OspC, Shigella

Xiaoyun Liu
contact affiliation	Peking University Health Science Center
contact email	xiaoyun.liu@bjmu.edu.cn
lab head
Zhiheng Tang
contact affiliation	Peking University Health Science Center
contact email	zhihengt@pku.edu.cn
dataset submitter

iProX dataset URI