PXD070325

PXD070325 is an original dataset announced via ProteomeXchange.

Title	Targeting Prolyl 3-hydroxylase 1 Inhibits Pancreatic Cancer Progression and Macrophage Immunity
Description	Using transcriptome sequencing, proteomic analyses and engineered mouse model, we have revealed a novel and pivotal role of Prolyl 3-hydroxylase 1 (P3H1) in PDAC. The expression of P3H1 is elevated in PDAC and correlates with poor outcomes in human patients. The genetic deletion of P3H1 in KPC mouse model (LSL-Kras G12D/+;Trp53loxP/loxP;Pdx1-Cre) significantly delays PDAC progression and alters immunosuppressive microenvironment, thereby prolonging mice survival.Our findings reveal a novel P3H1 target in PDAC progression and suggest a promising therapeutic strategy for PDAC treatment.
HostingRepository	PRIDE
AnnounceDate	2026-02-13
AnnouncementXML	Submission_2026-02-13_05:41:19.013.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	PANZHU BAI
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-04 16:27:55	ID requested
⏵ 1	2026-02-13 05:41:19	announced

Dataset with its publication pending

submitter keyword: P3H1, PLK1, chemotherapy, tumor microenvironment, Pancreatic ductal adenocarcinoma

Ying Sun
contact affiliation	Department of System Biology, School of Life Sciences, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Southern University of Science and Technology, Shenzhen, 518055, China.
contact email	suny@sustech.edu.cn
lab head
PANZHU BAI
contact affiliation	Southern University of Science and Technology
contact email	1591680145@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD070325

PRIDE project URI

• PRIDE
  1. PXD070325
     1. Label: PRIDE project
     2. Name: Targeting Prolyl 3-hydroxylase 1 Inhibits Pancreatic Cancer Progression and Macrophage Immunity