PXD070287

PXD070287 is an original dataset announced via ProteomeXchange.

Title	Hepatic metabolic reprogramming during short-term caloric restriction is driven by enhanced glucocorticoid rhythms.
Description	Caloric restriction (CR) improves metabolic health. To define how the hepatic glucocorticoid receptor (GR) supports CR-driven metabolic adaptation, we profiled its liver interactome by chromatin immunoprecipitation-mass spectrometry (ChIP-MS). Mouse livers were collected at ZT12 (glucocorticoid peak) under ad libitum or CR feeding. GR immunoprecipitates were compared to IgG controls to identify GR-associated proteins. The dataset reveals diet-dependent GR protein complexes, including transcriptional factors and metabolic coregulators, and serves as a resource for factors linking hormonal and nutritional signals to CR-induced hepatic reprogramming.
HostingRepository	PRIDE
AnnounceDate	2025-11-04
AnnouncementXML	Submission_2025-11-04_07:12:39.381.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Wierer
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-04 04:56:37	ID requested
⏵ 1	2025-11-04 07:12:39	announced

Dataset with its publication pending

submitter keyword: caloric restriction (CR)

liver metabolism

glucocorticoid signaling

ChIP-MS

protein-protein interactions

nutrient signaling

circadian rhythms

Nina Henriette Uhlenhaut
contact affiliation	Institute for Diabetes and Endocrinology (IDE) Helmholtz Zentrum München Ingolstaedter Landstr. 1 85764 Neuherberg, Germany
contact email	henriette.uhlenhaut@tum.de
lab head
Michael Wierer
contact affiliation	Proteomics Research Infrastructure, University of Copenhagen
contact email	michael.wierer@sund.ku.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD070287

PRIDE project URI

• PRIDE
  1. PXD070287
     1. Label: PRIDE project
     2. Name: Hepatic metabolic reprogramming during short-term caloric restriction is driven by enhanced glucocorticoid rhythms.