PXD070245

PXD070245 is an original dataset announced via ProteomeXchange.

Title	Dietary administration of a glycosylated form of vitamin D combined with natural triterpenes in late gestating and lactating sows
Description	This study evaluated the effects of dietary supplementation with a glycosylated form of active vitamin D (1,25(OH)₂D₃) combined with natural triterpenes (ursolic and oleanolic acids) in hyper-prolific sows during late gestation and lactation. Twenty-four Landrace × Large White sows were assigned to three experimental groups: a control diet (CTR) and two treatment diets supplemented with 0.64 µg/kg (ACTD1) or 0.96 µg/kg (ACTD2) of glycosylated 1,25(OH)₂D₃ combined with 140 or 210 µg/kg of triterpenes, respectively. Supplementation reduced farrowing duration and backfat thickness at weaning, while improving litter weight and piglet growth performance. Plasma analyses revealed lower levels of pro-inflammatory cytokines (TNF-α, IL-1α, IL-1β) and parathyroid hormone, alongside higher concentrations of calcitriol and calcium in treated sows. Proteomic profiling indicated modulation of lipid metabolism, coagulation, and vitamin D–related proteins, confirming systemic bioavailability of the supplemented compounds and their involvement in calcium and immune regulation. Overall, the combination of glycosylated calcitriol and triterpenes enhanced productivity, calcium homeostasis, and inflammatory balance in sows, supporting its potential as a nutritional strategy for improving reproductive efficiency and health under commercial farming conditions.
HostingRepository	PRIDE
AnnounceDate	2026-03-30
AnnouncementXML	Submission_2026-03-29_19:10:41.552.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Simona Nonnis
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-03 13:17:33	ID requested
⏵ 1	2026-03-29 19:10:42	announced

Marchetti L, Rebucci R, Giromini C, Maffioli EM, Tedeschi G, Bontempo V, Effects of a Glycosylated Form of Active Vitamin D Combined with Natural Triterpenes on Sow Productive Performance, Mineral Homeostasis, Immune Biomarkers and Serum Proteome. Vet Sci, 13(3):(2026) [pubmed]

10.3390/vetsci13030246;

submitter keyword: proteomic;nanoLC-MS/MS

elisa maffioli
contact affiliation	DIVAS, University of Milan
contact email	elisa.maffioli@unimi.it
lab head
Simona Nonnis
contact affiliation	University of Milan
contact email	simona.nonnis@unimi.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD070245

PRIDE project URI

• PRIDE
  1. PXD070245
     1. Label: PRIDE project
     2. Name: Dietary administration of a glycosylated form of vitamin D combined with natural triterpenes in late gestating and lactating sows