PXD070229

PXD070229 is an original dataset announced via ProteomeXchange.

Title	Evaluation of Ca37 monoclonal antibody against pathogenic fungal Candidozyma auris
Description	Candidozyma auris, previously known as Candida auris, is a recently found pathogenic yeast that causes systemic infections, showing a high mortality rate. Moreover, this species is highly resistant to the commonly used antifungal drugs and some of the strains are multiresistant. This fungus is also able to cause outbreaks in hospital settings. All of this has cause an alarm in the health care system. Therefore, finding alternative treatments for C. auris is critical. In this sense, our research group developed a monoclonal antibody (Ca37) against Candida albicans alcohol dehydrogenase enzyme (Adh) that successfully reduced the growth of the fungus in vitro and also showed a protective effect in vivo. Due to the high homology between both fungal alcohol dehydrogenases, we wanted to test the effect of Ca37 over C. auris. In order to do this, first we assessed if the monoclonal antibody also recognized C. auris Adh by sequencing the spots detected by two dimensional western blot when using the monoclonal antibody as first antibody. Two spots were detected in this western blot. The sequencing showed a mixture of proteins, but in both cases, Adh was one of the identified proteins.
HostingRepository	PRIDE
AnnounceDate	2026-01-05
AnnouncementXML	Submission_2026-01-04_16:08:23.235.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aitziber Antoran
SpeciesList	scientific name: [Candida] auris; NCBI TaxID: NEWT:498019;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-03 07:43:12	ID requested
⏵ 1	2026-01-04 16:08:24	announced

10.3390/jof11120864;

Rodriguez-Erenaga O, Areitio M, Abio-Dorronsoro L, Cazalis-Bereicua N, Aparicio-Fernandez L, Martin-Souto L, Buldain I, Zaldibar B, Rementeria A, Antoran A, Ramirez-Garcia A, ) In Vitro and In Vivo. J Fungi (Basel), 11(12):(2025) [pubmed]

submitter keyword: Fungi, Candidozyma auris, alcohol deshydrogenase, Monoclonal antibody

Andoni Ramirez Garcia
contact affiliation	Dept. Immunology, Microbiology and Parasitology Faculty of Science and Technology University of the Basque Country (UPV/EHU) Leioa, Spain
contact email	andoni.ramirez@ehu.eus
lab head
Aitziber Antoran
contact affiliation	University of the Basque Country (UPV/EHU)
contact email	aitziber.antoran@ehu.eus
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD070229

PRIDE project URI

• PRIDE
  1. PXD070229
     1. Label: PRIDE project
     2. Name: Evaluation of Ca37 monoclonal antibody against pathogenic fungal Candidozyma auris