PXD070147

PXD070147 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Patient-Derived Lung Tumoroids and Matched Organoids Compared to Parental Tumors and Tissues
Description	Proteomic characterization of patient-derived lung tumoroids and matched healthy lung organoids compared to their parental tumor and healthy lung tissues from NSCLC patients. The study validates that tumoroids preserve tumor-specific proteomic signatures and identifies proteomic signatures potentially driving resistance and susceptibility to standard of care and CAR T-cell therapy. Comparative analyses assess preservation of tumor proteomic landscapes, differential expression between tumor and healthy samples, and tumor-associated antigen expression profiles.
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-26_19:17:51.652.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lukas Ehlen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-31 03:18:13	ID requested
⏵ 1	2026-04-26 19:17:53	announced

10.1038/s41551-025-01594-3;

Ehlen L, Farrera-Sal M, Szyska M, Arndt J, Schallenberg S, Scholz C, Yang M, Vollbrecht C, L, ö, wa A, Friedrich R, Mai M, Peter L, Picht S, Schulenberg S, Geray D, Korus G, Sommerfeld A, Treue D, Strauchmann J, Elsner A, Kath J, Vallone VF, Joosten M, Klatte-Schulz F, Petersen A, Stachelscheid H, Wagner DL, Spies C, R, ü, ckert JC, Hocke AC, Polansky JK, Stark R, Klein O, Schmueck-Henneresse M, Lung tumouroids as a testing platform for precision CAR T cell therapy. Nat Biomed Eng, 10(4):815-831(2026) [pubmed]

submitter keyword: LC-MSMS,NSCLC, DIA-PASEF, CAR T cells, Tumoroids

Michael Schmueck-Henneresse
contact affiliation	Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Experimental Immunotherapy
contact email	michael.schmueck-henneresse@bih-charite.de
lab head
Lukas Ehlen
contact affiliation	Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Experimental Immunotherapy, Berlin, Germany and Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Berlin, Germany
contact email	lukas.ehlen@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD070147

PRIDE project URI

• PRIDE
  1. PXD070147
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Patient-Derived Lung Tumoroids and Matched Organoids Compared to Parental Tumors and Tissues