PXD070119

PXD070119 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteome of Coxsackievirus B3 infection models of human enterocyte cells
Description	Coxsackieviruses B (CVBs) emerge as candidate environmental triggers for the autoimmunity against pancreatic islet β cells leading to type 1 diabetes. Persistent CVB infections in the gut and pancreas correlate with islet autoantibody seroconversion, suggesting defective antiviral control in predisposed individuals. Recent antiviral and vaccine trials underscore the need to define immune mechanisms at the intestinal entry site. To address this, we investigated how CVB3 modulates antigen presentation in enterocytes and antigen-presenting cells by using immunopeptidomics and proteomics, and how these events shape downstream T-cell immunity.
HostingRepository	PRIDE
AnnounceDate	2026-05-07
AnnouncementXML	Submission_2026-05-07_03:43:09.547.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nicola Ternette
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-30 16:24:21	ID requested
⏵ 1	2026-05-07 03:43:10	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: Coxsackievirus B,autoimmunity, human leukocyte antigen (HLA), intestinal immunity, type 1 diabetes

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Coxsackievirus B,autoimmunity, human leukocyte antigen (HLA), intestinal immunity, type 1 diabetes

Contact List

Nicola Ternette
contact affiliation	University of Oxford University of Dundee
contact email	nicola.ternette@ndm.ox.ac.uk
lab head
Nicola Ternette
contact affiliation	University of Oxford
contact email	nicola.ternette@ndm.ox.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD070119
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD070119

PRIDE project URI

Repository Record List

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