PXD070075

PXD070075 is an original dataset announced via ProteomeXchange.

Title	Proteomic characterization of synaptosomes and sarkosyl-insoluble protein inclusions from Alzheimer's disease patients
Description	Alzheimer’s disease is characterized by neuropathological accumulation of amyloid plaques and neurofibrillary tangles composed of amyloid-beta peptides and hyperphosphorylated tau protein, respectively. These neuropathological changes alter the function of neurons, including synaptic contacts between interacting neurons, eventually resulting in neuronal dysfunction and neurodegeneration. Here, we simultaneously isolated nerve terminals (synaptosomes) and larger sarkosyl-insoluble protein inclusions from postmortem brains from Alzheimer’s disease and control cases and performed proteomic and phosphoproteomic analyses.
HostingRepository	PRIDE
AnnounceDate	2026-07-09
AnnouncementXML	Submission_2026-07-09_08:56:23.411.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sofie Blomberg Elmkvist
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; Orbitrap Fusion Lumos; Orbitrap Exploris 480; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-29 22:33:10	ID requested
⏵ 1	2026-07-09 08:56:23	announced

10.1021/ACS.JPROTEOME.5C01160;

submitter keyword: Human, synaptosomes, brain, Alzheimer's disease, sarkosyl-insoluble fraction

Martin Røssel Larsen
contact affiliation	Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
contact email	mrl@bmb.sdu.dk
lab head
Sofie Blomberg Elmkvist
contact affiliation	University of Southern Denmark
contact email	selmkvist@bmb.sdu.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD070075

PRIDE project URI

• PRIDE
  1. PXD070075
     1. Label: PRIDE project
     2. Name: Proteomic characterization of synaptosomes and sarkosyl-insoluble protein inclusions from Alzheimer's disease patients