PXD070054

PXD070054 is an original dataset announced via ProteomeXchange.

Title	Intergenerational and biochemical responses of the Western honey bee (Apis mellifera) to sublethal perfluorooctane sulfonate (PFOS) exposures.
Description	Bees are threatened by multiple stressors, including environmental contaminants such as perfluorooctane sulfonate (PFOS). In this exposure effect study, small whole colonies of A. mellifera (2500 bees) were exposed to sublethal PFOS concentrations (5 to 20 µg L-1 in sugar syrup) over a 25-day period using a purpose-built cage system. The PFOS was transferred to honey, accumulated in bee tissue, and was detected in faeces at all exposure concentrations. At the sublethal exposures, adult bee colonies in all treatments appeared healthy, colonies were sustained, brood was produced and resources stored, but adverse life stage development and intergenerational effects were evident even at the lowest exposure concentration of 5 µg L-1. Oxidative damage was not evident in bee heads based on protein carbonyl and malondialdehyde (MDA) biomarkers, but significant differential expression of some proteins essential for bee health was observed in the 10 (proteins n = 2) and 20 µg L-1 (proteins n = 15) exposure treatments. This study provides the first confirmation that sublethal PFOS exposure may adversely influence the long-term viability of honey bee colonies, and that PFOS will magnify in the bees and transfer to honey presenting a potential threat to food security and human health.
HostingRepository	PRIDE
AnnounceDate	2026-03-18
AnnouncementXML	Submission_2026-03-17_22:06:15.153.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rohan Lowe
SpeciesList	scientific name: Apis mellifera (Honeybee); NCBI TaxID: NEWT:7460;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-29 18:55:04	ID requested
⏵ 1	2026-03-17 22:06:16	announced

Sonter CA, Shakya M, Tighe M, Stevenson G, Datta K, Lowe RGT, Holland A, Rader R, Wilson SC, ) to Sublethal Perfluorooctanesulfonate (PFOS) Exposures. Environ Sci Technol, 60(8):5991-6001(2026) [pubmed]

10.1021/acs.est.5c08902;

submitter keyword: ecotoxicity, proteomics, honey, effects study, bee colony, oxidative stress,PFAS, cage, bee.

Carolyn A. Sonter
contact affiliation	University of New England, Madgwick Drive, Armidale, New South Wales, Australia
contact email	CSONTER2@UNE.EDU.AU
lab head
Rohan Lowe
contact affiliation	La Trobe University
contact email	r.lowe@latrobe.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD070054
     1. Label: PRIDE project
     2. Name: Intergenerational and biochemical responses of the Western honey bee (Apis mellifera) to sublethal perfluorooctane sulfonate (PFOS) exposures.