PXD070037

PXD070037 is an original dataset announced via ProteomeXchange.

Title	Decoding the phosphoproteomic signature of hallucinogenic psychedelics
Description	How psychedelic drugs generate altered states of consciousness while promoting enduring neuroplasticity remains a fundamental question in neuroscience with therapeutic implications. Here, we used quantitative phosphoproteomics in neural cultures to map intracellular signaling responses to serotonergic and non-serotonergic psychedelics. These compounds induced extensive remodeling of phosphorylation networks encompassing kinases, GPCRs, growth factor receptors, and epigenetic regulators. We uncovered a distinct phosphoproteomic signature that discriminates hallucinogenic from their non-hallucinogenic analogs, implicating pathways associated with metabolic regulation and neuroplasticity. Among these, phosphorylation of FOXK2, a glycolytic regulator, was specifically increased by hallucinogenic psychedelics. Functional validation confirmed that glycolytic activity is exclusively induced by this compound class. Our results define molecular architectures linking receptor activation to metabolic and structural plasticity, providing a framework for understanding the molecular basis of psychedelic action.
HostingRepository	PRIDE
AnnounceDate	2026-09-25
AnnouncementXML	Submission_2026-09-25_04:54:15.691.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD070037
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sandra M. Martin-Guerrero
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-29 09:03:23	ID requested
⏵ 1	2026-09-25 04:54:16	announced

10.6019/PXD070037;

10.1038/S41398-026-04390-Y;

submitter keyword: psychedelics, signalling, kinase, phosphoproteomics

Pedro R. Cutillas
contact affiliation	1. Barts Cancer Institute, Queen Mary University of London; Charterhouse Square, London EC1M 6BQ, UK. 2. Instituto de Parasitología y Biomedicina “López-Neyra” (IPBLN-CSIC); E-18016 Granada, Spain.
contact email	prcutillas@ipb.csic.es
lab head
Sandra M. Martin-Guerrero
contact affiliation	Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (CSIC)
contact email	sandrammg92@ipb.csic.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD070037

PRIDE project URI

• PRIDE
  1. PXD070037
     1. Label: PRIDE project
     2. Name: Decoding the phosphoproteomic signature of hallucinogenic psychedelics