PXD070030

PXD070030 is an original dataset announced via ProteomeXchange.

Title	Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice
Description	Colonization with Paleniella intestinalis bypasses genetic resistance, consistently72 inducing arthritis incidence in non-susceptible C57BL/6 mice; P. intestinalis activates colonic CD11b + CD11c+ myeloid cells, driving systemic Th1774 cell differentiation; In vitro, outer membrane vesicles from P. intestinalis or RA-derived S. copri RPC0176 primed DCs that drive Th17 differentiation in an IL-6-dependent manner;Transfer of P. intestinalis-primed DCs or its outer membrane vesicles alone increases78 arthritis incidence in non-susceptible C57BL/6 mice
HostingRepository	PRIDE
AnnounceDate	2025-11-20
AnnouncementXML	Submission_2025-11-20_01:35:13.623.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lena Riedinger
SpeciesList	scientific name: Palleniella intestinalis; NCBI TaxID: NEWT:2736291;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-29 05:36:39	ID requested
⏵ 1	2025-11-20 01:35:14	announced

Dataset with its publication pending

submitter keyword: Rheumatoid arthritis (RA), Prevotella, Th17 cells, Gut microbiota, Mucosal immunology, Outer membrane vesicles (OMV), IL-6, Gut-Joint axis, Dendritic cell (DC)

Monika Pischetsrieder
contact affiliation	Department of Chemistry and Pharmacy, Chair of Food Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nikolaus-Fiebiger-Str. 10, Erlangen 91058, Germany FAU NeW − Research Center New Bioactive Compounds, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Nikolaus-Fiebiger-Str. 10, Erlangen 91058, Germany
contact email	monika.pischetsrieder@fau.de
lab head
Lena Riedinger
contact affiliation	FAU Research Center New Bioactive Compounds (FAU NeW) Nikolaus-Fiebiger-Str. 10 91058 Erlangen, Germany
contact email	lena.riedinger@fau.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD070030

PRIDE project URI

• PRIDE
  1. PXD070030
     1. Label: PRIDE project
     2. Name: Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice