PXD069966

PXD069966 is an original dataset announced via ProteomeXchange.

Title	The Landscape of Nuclear tRNAs Import into Human Mitochondria Reveals VDAC as a General Gateway
Description	Mitochondria are critical sites for oxidative respiration and material exchange within mammalian cells. The mitochondrial genome encodes 22 types of tRNA and is responsible for the transcription and translation of 13 proteins involved in the oxidative respiratory chain. During the translation process, the tRNAs encoded by the mitochondrial genome decode 64 types of codons to ensure proper protein translation. The wobble hypothesis posits that mitochondrial tRNAs recognize codons through non-strict base pairing and specific modifications on the anticodon, thereby facilitating accurate decoding. However, it remains unclear whether nuclear-encoded tRNAs can enter the mitochondria and participate in mitochondrial translation.Existing studies have demonstrated that in lower organisms, the import of tRNAs into mitochondria requires the assistance of several cytosolic proteins to guide them to the mitochondrial surface, where they form RNA import complexes (RICs) with mitochondrial inner and outer membrane proteins
HostingRepository	iProX
AnnounceDate	2025-10-27
AnnouncementXML	Submission_2025-10-28_01:27:51.777.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Songwei Ai
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-28 01:27:39	ID requested
⏵ 1	2025-10-28 01:27:52	announced

Dataset with its publication pending

submitter keyword: mitochondrial channel,tRNA import,tRNA transport

Bo Cao
contact affiliation	Shanghai Jiao Tong University
contact email	caobosjtu@sjtu.edu.cn
lab head
Songwei Ai
contact affiliation	Shanghai Jiao Tong University
contact email	songwei_ai@sjtu.edu.cn
dataset submitter

iProX dataset URI