PXD069962

PXD069962 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic analysis of nascent chromatin in early versus late S phase
Description	The progression of replication forks is tightly regulated to ensure accurate genome duplication. We have found that these forks display biphasic dynamics throughout an unperturbed S phase, characterized by slow elongation in early S that transitions to rapid elongation in late S. In this study, we identify the molecular factors underlying this change by quantitatively profiling the proteins associated with nascent chromatin in early versus late S phase.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-07_04:27:15.314.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kristie Lindsey Rose
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	isotope labeled residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480; Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-27 20:33:41	ID requested
⏵ 1	2026-09-07 04:27:16	announced

Jayaprakash D, Patterson JG, Mulvaney R, Dickinson Q, Lovejoy C, Lerdrup M, Rivera-Mulia JC, Cortez D, Bhowmick R, Topological stress regulates replication fork dynamics in unperturbed S phase. Nat Commun, 17(1):(2026) [pubmed]

10.1038/s41467-026-73330-7;

submitter keyword: DNA replication, iPOND, cell cycle

Kristie Lindsey Rose
contact affiliation	Vanderbilt University, Proteomics Core
contact email	kristie.rose@vanderbilt.edu
lab head
Kristie Lindsey Rose
contact affiliation	Vanderbilt University
contact email	kristie.rose@vanderbilt.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD069962

PRIDE project URI

• PRIDE
  1. PXD069962
     1. Label: PRIDE project
     2. Name: Quantitative proteomic analysis of nascent chromatin in early versus late S phase