⮝ Full datasets listing
PXD069931
PXD069931 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting SF3A2 deacetylation promotes postinfarction cardiac pathological remodeling by reprogramming cardiomyocyte metabolism |
| Description | We investigated the function and mechanism of SF3A2 acetylation in heart infarction- and isoproterenol-induced pathological remodeling murine models to discover a theoretical basis for targeted treatment. Cardiomyocytes-specific mutation with adeno-associated virus 9 (AAV9) vector SF3A2-K174R or SF3A2-K174Q models combined with metabolomics, lipidomics,13C-glucose tracing, acetylomics were used to demonstrate mechanisms of SIRT7-mediated deacetylation of SF3A2-K10 in cardiac remodeling. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-27 |
| AnnouncementXML | Submission_2025-10-26_20:41:10.342.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qingxia Huang |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-26 20:40:46 | ID requested | |
| ⏵ 1 | 2025-10-26 20:41:12 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Cardiac pathological remodeling, acetylation, mitochondrial function |
Contact List
| Qingxia Huang | |
|---|---|
| contact affiliation | Changchun University of Chinese Medicine |
| contact email | hqx19890928@163.com |
| lab head | |
| Qingxia Huang | |
| contact affiliation | Changchun University of Chinese Medicine |
| contact email | hqx19890928@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
