⮝ Full datasets listing
PXD069901
PXD069901 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Vutiglabridin ameliorates obesity by directly reducing fat mass through AMPK/lipophagy activation in adipocytes |
| Description | Current anti-obesity therapies that suppress appetite often cause undesirable reductions in lean mass by indirectly depleting systemic energy store. In this study, we developed a novel anti-obesity drug, Vutiglabridin (VUTI), designed to selectively reduce fat mass while preserving lean mass. We evaluated its efficacy in high-fat diet–induced obese (DIO) mice and investigated its underlying mechanism in in vitro adipocyte models. VUTI dose-dependently and selectively decreased fat mass, resulting in normalization of body weight within 3 weeks while preserving lean mass. Pharmacokinetic and mechanistic analyses revealed that VUTI targets white adipose tissue (WAT), where it enhances lipid degradation through AMPK-mediated lipophagy in both mouse and human adipocytes. The lipid degradation-enhancing effect of VUTI was shown to be dependent on paraoxonase 2 (PON2). Multi-omics analyses, including proteomic and transcriptomic profiling of epididymal WAT in DIO-mice, further confirmed this mechanism. Collectively, these findings demonstrate that VUTI represents a promising therapeutic strategy for obesity by inducing fat-selective reduction via AMPK-mediated lipophagy. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-04-30 |
| AnnouncementXML | Submission_2026-04-29_18:46:31.119.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hyeong Min Lee |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; TMT; TMT |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-25 06:36:27 | ID requested | |
| ⏵ 1 | 2026-04-29 18:46:31 | announced |
Publication List
| Lee HM, Lee JH, Kim SH, Marakkalage KG, Hur J, Park HS, Kim KP, Shin GC, Yoo SK, Vutiglabridin ameliorates obesity by directly reducing fat mass through AMPK/lipophagy activation in adipocytes. Biomed Pharmacother, 193():118759(2025) [pubmed] |
Keyword List
| submitter keyword: Vutiglabridin |
| Obesity |
| Adipocytes |
| PON2 |
| AMPK |
| Lipophagy |
Contact List
| Sang-Ku Yoo | |
|---|---|
| lab head | |
| Hyeong Min Lee | |
| contact affiliation | Jeju univesity |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004140/ |
