PXD069897 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen |
| Description | Replicative senescence, a powerful tumor suppressor pathway, occurs when a few critically-short telomeres activate the DNA damage response (DDR). We show that ATM is the sole DDR kinase responsible for the induction and maintenance of replicative senescence and that ATM inhibition can induce normal cell divisions in senescent cells. Compared to non-physiological atmospheric (~20%) oxygen, cells grown at physiological (3%) oxygen were more tolerant to critically-short telomeres, explaining their extended replicative lifespan. We show that this tolerance is due to attenuation of the ATM response to double-strand breaks (DSBs) and unprotected telomeres. Our data indicate that the reduced ATM response to DSBs at 3% oxygen is due to increased ROS, which induces disulfide-bridges in ATM, generating crosslinked ATM dimers that do not respond to DSBs. This regulation of cellular lifespan through attenuation of ATM at physiological oxygen has implications for tumor suppression through telomere shortening. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-12 |
| AnnouncementXML | Submission_2026-02-12_08:08:06.164.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Henry Sanford |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-25 00:06:07 | ID requested | |
| ⏵ 1 | 2026-02-12 08:08:07 | announced | |
Publication List
| 10.1016/j.molcel.2025.11.006; |
| Stuart AJ, Takai KK, Gabbasova RR, Sanford H, Vinogradova EV, de Lange T, Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen. Mol Cell, 85(24):4667-4677.e7(2025) [pubmed] |
Keyword List
Contact List
| Dr Ekaterina |
|---|
| contact affiliation | Laboratory of Chemical Immunology and Proteomics, Rockefeller University |
| contact email | vinograd@rockefeller.edu |
| lab head | |
| Henry Sanford |
|---|
| contact affiliation | Rockefeller University |
| contact email | hsanford@rockefeller.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD069897 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069897
- Label: PRIDE project
- Name: Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen
