PXD069837

PXD069837 is an original dataset announced via ProteomeXchange.

Title	Adhesion-derived condensates control component availability to regulate adhesion dynamics
Description	Tensins are key components of integrin adhesions and play a key role in linking the actin cytoskeleton with the ECM through interaction with integrin heterodimers. While tensin 1 (TNS1) localises to both focal and fibrillar adhesions, TNS3 has been mostly associated with fibrillar adhesions. Tensins play a role in maintaining active integrin pools and adhesion reinforcement and facilitate tension-dependent focal adhesion maturation into centrally localized fibrillar adhesions. In addition, TNS1 forms functional and reversible condensates in cells in response to different extracellular stimuli that act as reservoirs of adhesion components. Here we perform proximity biotinylation proteomics (BioID) to identify proximity interactors of TNS1 and TNS3. In parallel, we focus on identifying condensation-dependent proximity interactors of TNS1 in cells with low and high TNS1 expression.
HostingRepository	PRIDE
AnnounceDate	2026-04-24
AnnouncementXML	Submission_2026-04-24_06:21:19.288.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michal Dibus
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	biotinylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-23 12:11:47	ID requested
⏵ 1	2026-04-24 06:21:19	announced

Dataset with its publication pending

submitter keyword: protein condensation, integrin adhesions, Tensin 3, phase separation,Tensin 1

Johanna Ivaska
contact affiliation	University of Turku, Turku Bioscience
contact email	joivaska@utu.fi
lab head
Michal Dibus
contact affiliation	University of Turku, Turku Bioscience
contact email	michal.dibus@utu.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD069837

PRIDE project URI

• PRIDE
  1. PXD069837
     1. Label: PRIDE project
     2. Name: Adhesion-derived condensates control component availability to regulate adhesion dynamics