PXD069813 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CD70 Regulates the NF1/Ras/ERK Axis to Promote Metastatic Potential in Clear Cell Renal Cell Carcinoma |
| Description | This study is the first report demonstrating a novel mechanism by which CD70 promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis, at least in part, through suppression of NF1 and subsequent activation of the Ras/ERK signaling pathway, which may further drive EMT-related features and enhance tumor metastatic potential. These insights provide a mechanistic rationale for targeting CD70, either alone or in combination with inhibitors of the Ras/ERK pathway or modulators of EMT, to impede metastasis in patients with advanced ccRCC. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-07_16:53:27.787.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jie Ni |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-23 00:36:03 | ID requested | |
| ⏵ 1 | 2026-06-07 16:53:28 | announced | |
Publication List
| Ni J, Gao A, Chen Y, He C, Wang X, Savelyeva N, Dong X, Wang Y, Wang M, CD70 regulates the NF1/Ras/ERK axis to promote metastatic potential in clear cell renal cell carcinoma. Cancer Cell Int, 26(1):(2026) [pubmed] |
| 10.1186/s12935-026-04277-4; |
Keyword List
| submitter keyword: EMT,CD70, NF1, Combination therapy, Ras/ERK pathway, Proteomics, Metastasis, ccRCC |
Contact List
| Jie Ni |
|---|
| contact affiliation | Academy of Pharmacy, Xi’an Jiaotong-Liverpool University, Suzhou, Jiangsu 215123, China |
| contact email | Jie.Ni22@student.xjtlu.edu.cn |
| lab head | |
| Jie Ni |
|---|
| contact affiliation | Xi’an Jiaotong-Liverpool University |
| contact email | jie.ni22@student.xjtlu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069813 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069813
- Label: PRIDE project
- Name: CD70 Regulates the NF1/Ras/ERK Axis to Promote Metastatic Potential in Clear Cell Renal Cell Carcinoma
