⮝ Full datasets listing
PXD069762
PXD069762 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | This study presents a global lactylome profiling of retinal tissues from diabetic retinopathy (DR) and control rats, revealing significant alterations in lysine lactylation that provide novel insights into the pathogenesis of DR |
| Description | Our comprehensive lactylome analysis delineates a compelling association between protein lactylation and diabetic retinopathy (DR). In the retinas of DR rats, we observed a marked imbalance in lactylation, with 55 sites on 49 proteins being significantly upregulated and 69 sites on 57 proteins downregulated compared to controls, highlighting the potential role of lactylation-driven pathways in DR pathology. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-21 |
| AnnouncementXML | Submission_2026-03-31_17:59:59.788.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jingjing Hou |
| SpeciesList | scientific name: Rattus rattus; NCBI TaxID: 10117; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-22 01:00:55 | ID requested | |
| ⏵ 1 | 2026-03-31 18:00:00 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Lactylation, diabetic retinopathy |
Contact List
| Zhengxuan Jiang | |
|---|---|
| contact affiliation | The Second Affiliated Hospital of Anhui Medical University |
| contact email | jiangzhengxuan@ahmu.edu.cn |
| lab head | |
| Jingjing Hou | |
| contact affiliation | The Second Affiliated Hospital of Anhui Medical University |
| contact email | hou052704@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
