PXD069754

PXD069754 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Profiling changes to the global proteome in HEK293T cells in response to heat stress. (PMID: 34739326)
Description	Here we have determined changes to the global proteome in response to heat stress. The abundance of individual proteins was compared between heat stressed and untreated control HEK293T cells in the presence of proteasome inhibition using quantitative proteomics.
HostingRepository	PRIDE
AnnounceDate	2025-10-22
AnnouncementXML	Submission_2025-10-22_13:00:01.857.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ashutosh Mishra
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	ubiquitination signature dipeptidyl lysine; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-21 20:52:00	ID requested
⏵ 1	2025-10-22 13:00:02	announced

Publication List

10.1126/science.abc3593;
Maxwell BA, Gwon Y, Mishra A, Peng J, Nakamura H, Zhang K, Kim HJ, Taylor JP, Ubiquitination is essential for recovery of cellular activities after heat shock. Science, 372(6549):eabc3593(2021) [pubmed]

10.1126/science.abc3593;

Maxwell BA, Gwon Y, Mishra A, Peng J, Nakamura H, Zhang K, Kim HJ, Taylor JP, Ubiquitination is essential for recovery of cellular activities after heat shock. Science, 372(6549):eabc3593(2021) [pubmed]

Keyword List

submitter keyword: proteasome,Stress response, ubiquitin, proteome

submitter keyword: proteasome,Stress response, ubiquitin, proteome

Contact List

J. Paul Taylor
contact affiliation	Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.
contact email	JPaul.Taylor@STJUDE.ORG
lab head
Ashutosh Mishra
contact affiliation	St. Jude Children's Research Hospital
contact email	ashutosh.mishra@stjude.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD069754
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD069754

PRIDE project URI

Repository Record List

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