PXD069736 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Long-read proteogenomic atlas of human neuronal differentiation |
| Description | This submission comprises the raw and processed mass spectrometry data from a high-resolution proteogenomic atlas established in iPSC-derived cortical neurons (a model of human neuron development). The data was collected using quantitative Tandem Mass Tag (TMT) proteomics and integrated with deep long-read RNA sequencing to expand the human proteome's functional landscape. Crucially, the mass spectrometry data provided direct peptide evidence supporting the translation of hundreds of novel protein-coding sequences derived from previously unknown mRNA isoforms. This resource was used to characterize dynamic protein isoform switching (including microexon usage and intron retention) within ASD risk genes during neuronal maturation, offering a critical foundation for reinterpreting pathogenic genetic variation in neurodevelopmental disorders. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-22 |
| AnnouncementXML | Submission_2026-07-22_02:47:13.765.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD069736 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Nuo Xu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-21 12:13:51 | ID requested | |
| ⏵ 1 | 2026-07-22 02:47:14 | announced | |
Publication List
Keyword List
| submitter keyword: Human, neurodevelopment, proteogenomics, iPSC |
Contact List
| Shreejoy Tripathy |
|---|
| contact affiliation | Centre for Addiction and Mental Health |
| contact email | shreejoy.tripathy@camh.ca |
| lab head | |
| Nuo Xu |
|---|
| contact affiliation | University of Toronto |
| contact email | nuoxu.xu@mail.utoronto.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD069736 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069736
- Label: PRIDE project
- Name: Long-read proteogenomic atlas of human neuronal differentiation
