PXD069681

PXD069681 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of bovine milk somatic cells in response to different bacterial specise
Description	Mastitis, one of the most significant diseases affecting dairy cattle, is caused by diverse bacterial pathogens that elicit distinct host immune responses. To gain deeper insight into the molecular mechanisms underlying these pathogen-specific interactions, we conducted a comprehensive proteomic analysis of bovine somatic cells isolated from milk in relation to the bacterial species present. The study included 56 quarter-level samples collected from 24 dairy cows. Samples were grouped according to pathogen categories based on the taxonomic similarity derived from 16S rRNA amplicon sequencing. Proteomic profiling revealed patterns of protein expression associated with mastitis in general, as well as distinct, pathogen-dependent signatures. This dataset provides valuable insights into host-pathogen interactions in the bovine mammary gland
HostingRepository	PRIDE
AnnounceDate	2026-04-17
AnnouncementXML	Submission_2026-04-17_05:10:57.397.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alicja Krysmann
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: NEWT:9913;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-20 12:24:28	ID requested
⏵ 1	2026-04-17 05:10:57	announced

10.1186/S13567-026-01754-6;

submitter keyword: mastitis, sometic cells,bovine, proteome

Davide Porcellato
contact affiliation	Norwegian University of Life Sciences
contact email	davide.porcellato@nmbu.no
lab head
Alicja Krysmann
contact affiliation	Norwegian University of Life Sciences
contact email	alicja.monika.krysmann@nmbu.no
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD069681
     1. Label: PRIDE project
     2. Name: Proteomic profiling of bovine milk somatic cells in response to different bacterial specise