PXD069666 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tbr1+/- Mouse whole brain, cocktail treatment |
| Description | Autism spectrum disorders (ASD) are a group of heterogeneous, behaviourally defined neurodevelopmental conditions influenced by both genetic and environmental factors. Here, we show that supplementation of low-dose multiple nutrients (an important environmental factor) can modulate synaptic proteomes, reconfigure neural ensembles, and improve social behaviours in mice. We first used Tbr1+/- mice, a well-established model of ASD, to investigate the effect of 1/4 cocktail (containing Ile 0.1125%, Leu 0.225%, Val 0.1125%, 1% serine and 20 ppm zinc) in drinking water. To define the total proteomes after seven days supplementation of nutrient cocktails treatment alters in mouse cortex by LC-MsMS. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-31 |
| AnnouncementXML | Submission_2025-10-31_00:48:21.926.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tzyy_Nan Huang |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-20 05:26:14 | ID requested | |
| ⏵ 1 | 2025-10-31 00:48:22 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
Contact List
| Hsueh, Yi-Ping |
|---|
| contact affiliation | Institute of Molecular Biology Academia Sinica Taipei Taiwan |
| contact email | yph@as.edu.tw |
| lab head | |
| Tzyy_Nan Huang |
|---|
| contact affiliation | Institute of Molecular Biology
Academia Sinica |
| contact email | eugene02@as.edu.tw |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD069666 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069666
- Label: PRIDE project
- Name: Tbr1+/- Mouse whole brain, cocktail treatment
