PXD069645

PXD069645 is an original dataset announced via ProteomeXchange.

Title	Regulation of Enrofloxacin drug resistance in bovine Pasteurella multocida strains by quorum-sensing acyl-homoserine lactone signaling molecules
Description	Pasteurella multocida (Pm) is an important pathogen causing respiratory disease in beef cattle, often forming mixed infections with Mycoplasma bovis and other pathogens, seriously jeopardizing the healthy development of the cattle industry. Fluoroquinolones and other broad-spectrum antimicrobials are commonly used in clinical treatment of bovine pasteurellosis. However, due to long-term and widespread use of these drugs, this pathogen has developed resistance to multiple antimicrobial agents. The quorum sensing (QS) system serves as a crucial mechanism for bacterial communication and has been confirmed to extensively participate in regulating key biological processes including bacterial virulence expression, biofilm formation, bacterial growth, antibiotic resistance, and symbiosis. Among these, the Type I QS system is primarily found in Gram-negative bacteria and functions mainly through acyl-homoserine lactone signaling molecules. In this study, we added 200 mg/L of the C6 signal molecule and performed transcriptomic, proteomic, and metabolomic sequencing on the sub-inhibitory concentration treatment group (Pm-E1), sub-inhibitory concentration plus C6 treatment group (Pm-E2), and control group (Pm-YQ) to investigate its regulatory mechanism on enrofloxacin（ENR） resistance in Pm.
HostingRepository	iProX
AnnounceDate	2025-10-18
AnnouncementXML	Submission_2025-10-20_02:00:12.977.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Miao Sun
SpeciesList	scientific name: Pasteurella multocida subsp. multocida str. Anand1_cattle; NCBI TaxID: 1032867;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-20 02:00:00	ID requested
⏵ 1	2025-10-20 02:00:13	announced

Dataset with its publication pending

submitter keyword: Pasteurella multocida, drug resistance, quorum-sensing molecule, proteome sequencing.

Zi Wang
contact affiliation	Inner Mongolia Minzu University
contact email	wangzixiaoxu@163.com
lab head
Miao Sun
contact affiliation	Inner Mongolia Minzu University
contact email	15947674804@163.com
dataset submitter

iProX dataset URI