PXD069640
PXD069640 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling of Microsporum canis Unveils the Fungicidal Mechanisms of Methylene Blue-Mediated Photodynamic Therapy |
| Description | This study applied an integrated DIA proteomics and untargeted metabolomics approach to investigate the molecular responses of Microsporum canis following methylene blue-mediated photodynamic therapy (MB-PDT). The combined datasets revealed widespread and coordinated changes across protein expression and metabolite pools. MB-PDT induced a systemic, multi-targeted disturbance of fungal physiology that converges on cellular energetics, proteostasis, membrane integrity, virulence determinants, and stress-response networks. Key mechanisms included disruption of membrane integrity, downregulation of virulence factors like secreted proteases, and impairment of the antioxidant defense system. The findings suggest that MB-PDT exerts its fungicidal effect through a multi-pronged mechanism, providing novel insights and supporting its development as an effective therapy for dermatophytosis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-20 |
| AnnouncementXML | Submission_2025-10-20_01:52:56.187.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gaoyuan Peng |
| SpeciesList | scientific name: Microsporum canis; NCBI TaxID: 63405; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Thermo Fisher Scientific instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-20 01:52:04 | ID requested | |
| ⏵ 1 | 2025-10-20 01:52:56 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Antifungal mechanism, Microsporum canis, Photodynamic therapy, Proteomics, Metabolomics |
Contact List
| Xinyu Zhang | |
|---|---|
| contact affiliation | The First Affiliated Hospital of Guangxi Medical University |
| contact email | zhangxinyugx@163.com |
| lab head | |
| Gaoyuan Peng | |
| contact affiliation | The First Affiliated Hospital of Guangxi Medical University |
| contact email | penggaoyuan@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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