PXD069615 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cellular proteome changes occuring in HeLa human cells upon incubation with retro2-derived chemical probes based on PROTAC technology |
| Description | The proteomes of human HeLa cells were established by comprehensive label-free shotgun proteomics upon incubation with chemical probes for 6 hours. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-24 |
| AnnouncementXML | Submission_2026-02-24_04:02:05.649.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jean ARMENGAUD |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-18 00:04:26 | ID requested | |
| ⏵ 1 | 2026-02-24 04:02:06 | announced | |
Publication List
| 10.1016/j.ejmech.2026.118645; |
| Michon M, Curpanen S, Pessey O, Thai R, Gaillard JC, Herbette G, Hinsinger K, Gillet D, Armengaud J, Cintrat JC, Barbier J, Synthesis and biological evaluation of Retro-2-based PROTACs reveal PEG-linker length and warhead impact on GSPT1 degradation. Eur J Med Chem, 307():118645(2026) [pubmed] |
Keyword List
| submitter keyword: proteomics, chemical probes, PROTAC, protein degradation, neosubstrate |
Contact List
| Jean Armengaud |
|---|
| contact affiliation | CEA-Marcoule, ProGenoMIX platform, DRF-Li2D, 30207 Bagnols-sur-Ceze, France |
| contact email | jean.armengaud@cea.fr |
| lab head | |
| Jean ARMENGAUD |
|---|
| contact affiliation | Li2D |
| contact email | jean.armengaud@cea.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD069615 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069615
- Label: PRIDE project
- Name: Cellular proteome changes occuring in HeLa human cells upon incubation with retro2-derived chemical probes based on PROTAC technology
