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PXD069597
PXD069597 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Plasma Proteomics Analysis of a Transglutaminase 2 inhibitor in Celiac Disease |
| Description | Individuals with celiac disease (CeD) on a long-term gluten-free diet (GFD) underwent a 6-week gluten challenge combined with 100mg per day of the transglutaminase 2 enzyme -inhibitor, ZED1227 (PGCd, n = 28) or placebo (PGCp, n = 19). The samples were collected at baseline (GFD) and post-gluten challenge (PGC). Mass spectrometry-based lipidomic and proteomics profiling, along with genome-wide DNA methylation analysis, were applied to plasma samples obtained from 47 CeD patients. Comparative analyses were performed between the groups, with adjustment for BMI, age, sex, and country of origin. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-14_17:12:51.855.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Robert Moulder |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-17 11:31:52 | ID requested | |
| ⏵ 1 | 2026-06-14 17:12:52 | announced |
Publication List
| 10.1186/s12916-026-04892-y; |
| 10.1038/s41590-024-01867-0; |
| Dotsenko V, Le HH, Raji, ć S, Moulder R, Kettunen J, Hirvonen MK, Dickens AM, Hy, ö, tyl, ä, inen T, Tewes B, Zimmermann T, Mohrbacher R, Suomi T, Lehtim, ä, ki T, Lahesmaa R, Ore, š, i, č M, Elo LL, Raitoharju E, Schuppan D, M, ä, ki M, Viiri K, Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease. BMC Med, 24(1):(2026) [pubmed] |
Keyword List
| submitter keyword: Human, LC_MSMS, Celiac disease, Plasma |
Contact List
| Professor Riitta Lahesmaa | |
|---|---|
| contact affiliation | Turku Bioscience Centre, University of Turku and Åbo Akademi University |
| contact email | rilahes@utu.fi |
| lab head | |
| Robert Moulder | |
| contact affiliation | Turku Biosciences |
| contact email | rmoulder@btk.fi |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069597 |
| PRIDE project URI |
Repository Record List
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