PXD069566 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TMT-based quantitative proteomic analysis of Staphylococcus aureus resistant to polyhexamethylene biguanide (PHMB) |
| Description | This project explores the proteomic alterations associated with polyhexamethylene biguanide (PHMB) resistance in Staphylococcus aureus using tandem mass tag (TMT)-based quantitative proteomics. PHMB-resistant and control strains were compared to identify proteins involved in resistance mechanisms, particularly those related to cell envelope modification and surface charge regulation. Proteins encoded by the dlt operon were found to be significantly upregulated in the resistant strain, suggesting their involvement in PHMB tolerance and potential cross-resistance to other antibiotics. This dataset provides comprehensive proteomic evidence for understanding the molecular basis of PHMB-induced resistance in S. aureus. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-08 |
| AnnouncementXML | Submission_2025-11-08_06:12:00.944.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huaixin Zheng |
| SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: NEWT:1280; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-16 21:45:49 | ID requested | |
| ⏵ 1 | 2025-11-08 06:12:01 | announced | |
Publication List
Keyword List
| submitter keyword: cell wall modification, TMT proteomics, DltC, PHMB resistance,Staphylococcus aureus, LC–MS/MS, antimicrobial resistance |
Contact List
| Huaixin Zheng |
|---|
| contact affiliation | Department of Microbiology and lmmunology, School of Basic Medical Sciences, ZhengzhouUniversity, Zhengzhou, China |
| contact email | huaixin_zheng@zzu.edu.cn |
| lab head | |
| Huaixin Zheng |
|---|
| contact affiliation | Zhengzhou University |
| contact email | huaixin_zheng@zzu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD069566 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069566
- Label: PRIDE project
- Name: TMT-based quantitative proteomic analysis of Staphylococcus aureus resistant to polyhexamethylene biguanide (PHMB)
