PXD069474

PXD069474 is an original dataset announced via ProteomeXchange.

Title	Hepatic LONP1 Overexpression Ameliorates Hepatic Steatosis and Fibrosis in mice
Description	Compared to control mice, liver-specific overexpression of LONP1 alleviated hepatic steatosis and attenuated fibrosis progression in MASH mice. Liver samples from three control mice injected with AAV-3×flag and fed a CDAHFD for 8 weeks were used as the control group, while those from three mice injected with AAV-TBG-Lonp1 and similarly fed served as the treatment group (with successful viral overexpression). Proteomic sequencing was performed on liver samples from both groups to further investigate the mechanism by which LONP1 overexpression improves MASH.
HostingRepository	iProX
AnnounceDate	2025-10-15
AnnouncementXML	Submission_2025-11-17_22:56:14.410.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Monan Liu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-15 01:13:35	ID requested
⏵ 1	2025-11-17 22:56:15	announced

Liu M, Chen M, Weng J, Xu S, Hepatic LONP1 overexpression ameliorates hepatic steatosis and fibrosis in mice. J Hepatol, ():(2025) [pubmed]

submitter keyword: LONP1, MASH, fiborsis

Suowen Xu
contact affiliation	University of Science and Technology of China
contact email	sxu1984@ustc.edu.cn
lab head
Monan Liu
contact affiliation	University of Science and Technology of China
contact email	liumonan@mail.ustc.edu.cn
dataset submitter

iProX dataset URI