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PXD069462

PXD069462 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Discovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos
Description	Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, positioning it as a promising starting point for the treatment of HCC and a promising chemical probe for investigating the non-necroptotic functions of MLKL.
HostingRepository	iProX
AnnounceDate	2025-10-14
AnnouncementXML	Submission_2025-10-14_18:59:53.538.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinlei Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	ZenoTOF 7600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-14 18:59:33	ID requested
⏵ 1	2025-10-14 18:59:54	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: HCC;MLKL

Contact List

Jing Ai
contact affiliation	Shanghai Institute of Materia Medica
contact email	jai@simm.ac.cn
lab head
Xinlei Wang
contact affiliation	Shanghai Institute of Materia Medica
contact email	wangxinlei@simm.ac.cn
dataset submitter

Full Dataset Link List

iProX dataset URI