PXD069444

PXD069444 is an original dataset announced via ProteomeXchange.

Title	Spatial proteomics for the analysis of host-pathogen interactions in mice lungs infected with Aspergillus fumigatus
Description	Laser-based tissue microdissection of lungs from mice infected with A. fumigatus and the subsequent MALDI Imaging MS offers the possibility to excise defined regions and transfer them to the more sensitive and deeper LC-MS/MS-based proteome analysis. In case of host-pathogen interaction between mammalian cells and pathogenic fungi like A. fumigatus this combination opens up the possibility to elucidate this biological cross-talk together with spatial Information on the invasive fungal infection. Here, we provide for the first time insights into the in vivo proteome of murine lungs infected by A. fumigatus using MALDI-IMS and laser microdissection.
HostingRepository	PRIDE
AnnounceDate	2026-03-24
AnnouncementXML	Submission_2026-03-24_07:35:13.141.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD069444
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Thomas Krüger
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; scientific name: Neosartorya fumigata (Aspergillus fumigatus); NCBI TaxID: NEWT:746128;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-14 07:24:20	ID requested
⏵ 1	2026-03-24 07:35:13	announced

10.1093/FEMSML/UQAG010;

10.6019/PXD069444;

submitter keyword: Spatial proteomics for the analysis of host-pathogen interactions in mice lungs infected with Aspergillus fumigatus

Axel A. Brakhage
contact affiliation	Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology / Hans Knöll Institute Jena (Leibniz-HKI), Jena, Germany
contact email	axel.brakhage@leibniz-hki.de
lab head
Thomas Krüger
contact affiliation	Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
contact email	thomas.krueger@leibniz-hki.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD069444

PRIDE project URI

• PRIDE
  1. PXD069444
     1. Label: PRIDE project
     2. Name: Spatial proteomics for the analysis of host-pathogen interactions in mice lungs infected with Aspergillus fumigatus