PXD069436 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers |
| Description | Non-Muscle Invasive Bladder Cancer (NMIBC) includes High-Grade (HG) and Low-Grade (LG) variants, classified by aggressiveness, recurrence risk, and tumor stage—either non-invasive (pTa) or invading the lamina propria (pT1). Cystoscopy is the diagnostic gold standard, with no less invasive alternatives, and the molecular mechanisms driving tumorigenesis and therapy response remain poorly understood. To address this, we conducted a preliminary proteomic study on pTa-LG and pT1-HG NMIBC fresh biopsies at first diagnosis to understand molecular differences and identify potential prognostic biomarkers. Proteomic analysis revealed distinct protein signatures between tumor stages. In pT1-HG, up-regulated proteins were linked to nitric oxide biosynthesis, signal transduction, apoptosis regulation, protein folding, and immune response. PT1-HG down-regulated proteins were involved in cellular localization, cytoskeleton organization, cell adhesion, phagocytosis, and tissue development. Notably, several proteoforms of PDC6I, a protein regulating apoptosis and proliferation, were down-regulated in pT1-HG. Additionally, protein abundance of GANAB, GALE, HNRNPH1, THIC, SEPT8 and MYDGF/C19orf10 was correlated with tumor size, indicating potential as prognostic biomarkers. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-04_16:08:23.642.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lorenza Vantaggiato |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | ultraflex |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-14 02:50:25 | ID requested | |
| ⏵ 1 | 2026-01-04 16:08:24 | announced | |
Publication List
| 10.3390/proteomes13040065; |
| Vantaggiato L, Frisenda M, Shaba E, Splendore C, Sciarra B, Bini L, Sciarra A, Landi C, Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers. Proteomes, 13(4):(2025) [pubmed] |
Keyword List
| submitter keyword: NMIBC |
| Tumor stage |
| proteomics |
| Prognostic markers |
| PDC6I; |
Contact List
| CLAUDIA LANDI |
|---|
| contact affiliation | Functional Proteomics Lab, Department of Life Sciences, University of Siena, Siena , 53100 Italy |
| contact email | claudia.landi@unisi.it |
| lab head | |
| Lorenza Vantaggiato |
|---|
| contact affiliation | University of Siena |
| contact email | lorenz.vantaggiato2@unisi.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD069436 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069436
- Label: PRIDE project
- Name: Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic Biomarkers
