PXD069411
PXD069411 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Several different proteins have been identified to be related to cognitive and social functions in patients with schizophrenia |
| Description | Mass spectrometry-based proteomics is a powerful analytical technique for identifying and quantifying proteins in the human plasma, which may be related to the onset, course or the prognosis of schizophrenia. Our study enrolled 46 schizophrenia patients and 43 healthy controls, who were collected morning fasting venous blood and completed scale assessment. Then mass spectrometry analysis was performed to identify differential proteins and correlation analysis was conducted to explore the relationship between protein biomarkers and psychiatric symptoms, cognitive function and social function in schizophrenia patients. Compared with the control group, the patient group showed lower immediate and delayed accuracy rates in pattern recognition memory. Alpha-actinin-1 and profilin-1 were positively associated with immediate pattern recognition accuracy. Both were also negatively associated with total number of errors of spatial working memory. Meanwhile, filamin-A was positively associated with immediate accuracy rate and delay accuracy rate of pattern recognition memory. In addition, integrin alpha-M was negatively correlated with factor I of the scale of social function and glutathione synthetase was positively correlated with the total score, factor Ⅰ, factor Ⅱ and factor Ⅲ of the scale of social function in psychosis inpatients. Our study indicated that alpha-actinin-1, profilin-1 and filamin-A may be related to cognitive functions, integrin alpha-M and glutathione synthase may be related to social function outcome of schizophrenia patients. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-14 |
| AnnouncementXML | Submission_2025-10-13_18:25:44.262.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaoqian Fu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-13 18:25:27 | ID requested | |
| ⏵ 1 | 2025-10-13 18:25:44 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: schizophrenia, proteomics, biomarkers |
Contact List
| Xiangdong Du | |
|---|---|
| contact affiliation | Medical College of Soochow University; Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow University |
| contact email | xiangdong-du@163.com |
| lab head | |
| Xiaoqian Fu | |
| contact affiliation | Medical College of Soochow University; Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow University |
| contact email | a126fuxiaoqian@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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