⮝ Full datasets listing
PXD069404
PXD069404 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive and Rapid Analysis of Post-Translational Modifications in In Diabetic Women with a History of Gestational Diabetes |
| Description | This work describes the development and validation of a high throughput proteomics workflow that enables combined profiling of global proteomes and post-translational modifications (PTMs) without conventional enrichment or fractionation. Using mass spectrometry-based methods, we identified PTM landscapes, particularly N-glycopeptides and non-enzymatic glycated peptides, from the same sample prepared for global proteomics. By applying this methodology to evaluate longitudinal serum samples from women at 6 and 10 years following gestational diabetes mellitus (GDM), we identified PTM signatures, including N-glycosylation and non-enzymatic glycation. Our study identified modified peptide signatures associated with development of type 2 diabetes (T2D) and prediabetes, which were validated in an independent T2D cohort. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-09-01 |
| AnnouncementXML | Submission_2026-09-01_09:33:05.929.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Philip To |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | unknown modification; Acetyl; Oxidation; Carbamidomethyl; Hex |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-13 11:04:10 | ID requested | |
| ⏵ 1 | 2026-09-01 09:33:06 | announced |
Publication List
| To P, Kale S, Partlow S, Wallenius K, Holm, รค, ng A, Andersson-Hall U, Allman EL, Hess S, Chung HS, Rapid serum proteome profiling of glycation and N-glycosylation in women with a history of gestational diabetes. Mol Omics, 22(4):(2026) [pubmed] |
Keyword List
| submitter keyword: Clinical Proteomics, Diabetes, N-Glycosylation, Non-enzymatic glycation, DatasetType:Proteomics |
Contact List
| Sophia Chung | |
|---|---|
| contact affiliation | AstraZeneca |
| contact email | sophia.chung@astrazeneca.com |
| lab head | |
| Philip To | |
| contact affiliation | AstraZeneca |
| contact email | philip.to@astrazeneca.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099469/ |
