PXD069401 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mitoxantrone impacts on proteoform abundance in HR proficient and deficient ovarian cancer cells |
| Description | Mitoxantrone (MX) is regularly used to treat several cancers, yet despite its long history in the clinic, recent studies continue to unveil novel protein targets that may contribute to the cytotoxic effects of the drug, as well as potential non-canonical antitumor activity. A better understanding of MX’s cellular targets is required to fully comprehend the molecular consequences of treatment and to interpret MX-sensitivity in homologous recombination (HR)-deficient cancer. The mass spectrometry samples reported here represent the analysis of MX impacts on proteoform abundance in HR-deficient or proficient UWB1.289 ovarian cancer cells using TMT-labeled quantitative proteomics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-01 |
| AnnouncementXML | Submission_2025-11-30_16:33:51.405.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Nicholas Woods |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-13 08:59:30 | ID requested | |
| ⏵ 1 | 2025-11-30 16:33:52 | announced | |
Publication List
| Wallin S, Pandithar S, Singh S, Kumar S, Natarajan A, Borgstahl GEO, Woods N, Surveying the Proteome-Wide Landscape of Mitoxantrone and Examining Drug Sensitivity in BRCA1-Deficient Ovarian Cancer Using Quantitative Proteomics. Proteomes, 13(4):(2025) [pubmed] |
| 10.3390/proteomes13040061; |
Keyword List
| submitter keyword: ovarian cancer,Mitoxantrone |
Contact List
| Nicholas Woods |
|---|
| contact affiliation | Eppley Institute for Research in Cancer University of Nebraska Medical Center |
| contact email | nicholas.woods@unmc.edu |
| lab head | |
| Nicholas Woods |
|---|
| contact affiliation | University of Nebraska Medical Center - Eppley Institute for Research in Cancer |
| contact email | nicholas.woods@unmc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069401
- Label: PRIDE project
- Name: Mitoxantrone impacts on proteoform abundance in HR proficient and deficient ovarian cancer cells
