PXD069391

PXD069391 is an original dataset announced via ProteomeXchange.

Title	DVE-1 is telomere-binding protein and links the NuRD complex to telomere regulation in C.elegans
Description	Telomeres comprise repetitive DNA sequences bound by specialized proteins at the end of linear chromosomes. Although some proteins have been identified and characterized in the nematode Caenorhabditis elegans, additional remain to be discovered, validated, and characterized. In our previous quantitative proteomics screen for telomere-binding proteins of C. elegans, we identified several candidates. One of these candidates was the homeobox protein DVE-1, a homolog of mammalian SATB proteins and transcription factor that plays a central role in the mitochondrial unfolded protein response. In this study, we validate DVE-1 as a telomere-binding protein in C. elegans. We show in vitro binding of DVE-1 to telomeric sequences and in vivo co-localization with the known telomere binding protein POT-1. Further, these results are supported by findings of DVE-1 ChIPseq analysis and RNA interference experiments followed by transcriptome and proteome analysis. Finally, we identified all core members of the nucleosome remodeling and deacetylase (NuRD) complex by DVE-1 immunoprecipitation and subsequent mass spectrometry experiments and bring them in the context of telomere organization.
HostingRepository	PRIDE
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-15_05:18:19.883.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	F Butter
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: NEWT:6239;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF HT; Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-13 06:19:16	ID requested
⏵ 1	2026-06-15 05:18:20	announced

Dataset with its publication pending

submitter keyword: LC-MS/MS

Falk Butter
contact affiliation	Institute of Molecular Biology (IMB)
contact email	f.butter@imb.de
lab head
F Butter
contact affiliation	Quantitative Proteomics Institute of Molecular Biology (IMB)
contact email	f.butter@imb-mainz.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069391

PRIDE project URI

• PRIDE
  1. PXD069391
     1. Label: PRIDE project
     2. Name: DVE-1 is telomere-binding protein and links the NuRD complex to telomere regulation in C.elegans