PXD069336 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic selectivity of BTK-targetting probes derivatizes with thiohaloacetamide warheads |
| Description | Mino cell lysates were incubated with alkyne-modified probes derived from ibrutinib, containing either acrylamide, chloro/fluoro acetamide or thiochloro/thiofluoro acetamide warheads. The reacted proteins were enriched and quantified using DIA. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_17:10:15.331.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ronen Gabizon |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-10 18:08:29 | ID requested | |
| ⏵ 1 | 2026-09-06 17:10:16 | announced | |
Publication List
| 10.1038/s41467-026-72993-6; |
| Petri L, Gabizon R, P, é, czka N, Á, br, á, nyi-Balogh P, Simon J, Imre T, Ferenczy GG, London N, Keser, ű GM, -Halothioamide warheads with enhanced cysteine reactivity and specificity for covalent protein labelling. Nat Commun, 17(1):(2026) [pubmed] |
Keyword List
| submitter keyword: ibrutinib,BTK, alkyne probe |
Contact List
| Nir London |
|---|
| contact affiliation | Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel |
| contact email | nir.london@weizmann.ac.il |
| lab head | |
| Ronen Gabizon |
|---|
| contact affiliation | Department of Chemical and Structural Biology, Weizmann Institute of Science |
| contact email | ronen.gabizon@weizmann.ac.il |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD069336 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069336
- Label: PRIDE project
- Name: Proteomic selectivity of BTK-targetting probes derivatizes with thiohaloacetamide warheads
