PXD069291

PXD069291 is an original dataset announced via ProteomeXchange.

Title	Study on the protective effects and molecular mechanisms of L-sodium lactate in mouse colitis
Description	The therapeutic potential of L-sodium lactate was investigated in a dextran sodium sulfate (DSS)-induced colitis model. Treatment with L-sodium lactate significantly mitigated disease severity, as evidenced by reduced colon shortening (P < 0.05) and elevated levels of the anti-inflammatory cytokine IL-10 (P < 0.05). Tandem mass tag (TMT)-based proteomic profiling revealed dual mechanisms, including the upregulation of cell cycle- and proliferation-associated proteins (PCNA, SMC, eEF2K) and the downregulation of immune-related proteins (immunoglobulin variants, Granzyme A). In vitro, 10 μM L-sodium lactate promoted the proliferation and migration of colorectal cancer cells （MC38/HCT116）（P < 0.05），accompanied by increased expression of c-Myc and PCNA. Collectively, these findings identify L-sodium lactate as a key metabolite that enhances mucosal repair while suppressing inflammation.
HostingRepository	iProX
AnnounceDate	2025-10-10
AnnouncementXML	Submission_2025-10-10_01:12:35.482.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kangping Shao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive; Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-10 01:07:58	ID requested
⏵ 1	2025-10-10 01:12:36	announced

Dataset with its publication pending

submitter keyword: L-sodium lactate, colitis, proteomics, cell cycle

Pan Huang
contact affiliation	School of Medicine, Jiangsu University
contact email	phuang@ujs.edu.cn
lab head
Kangping Shao
contact affiliation	School of Medicine, Jiangsu University
contact email	zhuanye268@foxmail.com
dataset submitter

iProX dataset URI