PXD069238

PXD069238 is an original dataset announced via ProteomeXchange.

Title	PhastID reveals STRBP/ILF3L as a central hub connecting S-phase telomerase recruitment with nuclear GEM bodies
Description	Telomere maintenance is essential for genome stability, and its regulation during the cell cycle remains a critical area of research. Screening for telomerase-interacting proteins is crucial for understanding the biological processes of telomerase maturation, processing, and recruitment. Using PhastID screening with TERT during S-phase, we identify STRBP, a GEMs-associated protein, as a novel regulator of telomerase activity and telomere length. Our data demonstrate that STRBP mediates interaction with telomerase through TERRA, this interaction negatively regulates telomerase activity, thereby limiting telomere elongation. Notably, TERRA levels decrease during S-phase, potentially facilitating the recruitment of telomerase to telomeres and enabling telomere extension.
HostingRepository	iProX
AnnounceDate	2025-10-09
AnnouncementXML	Submission_2025-10-09_02:06:30.292.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuanle Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-09 02:06:10	ID requested
⏵ 1	2025-10-09 02:06:30	announced

Dataset with its publication pending

submitter keyword: PhastID, STRBP/ILF3L, S-phase telomerase recruitment, GEM bodies

Yan Huang
contact affiliation	Sun Yat-sen University
contact email	huangy336@mail.sysu.edu.cn
lab head
Chuanle Wang
contact affiliation	Sun Yat-sen University
contact email	1415849898@qq.com
dataset submitter

iProX dataset URI