PXD069236
PXD069236 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-omics profiling reveals the biological features of CMV reactivation in ARDS patients |
| Description | Cytomegalovirus (CMV) can be reactivated in patients with acute respiratory distress syndrome (ARDS), a condition associated with poor prognosis. However, the biological characteristics of CMV reactivation remain unclear. Here we built a multi-omics profiling database using blood plasma and bronchoalveolar lavage fluid (BALF) from 151 ARDS cohort, with 47 in CMV reactivation group and 104 in no reactivation group. Proteomic analyses revealed suppression of immune, complement, and ribosomal subunit biogenesis pathways in BALF, along with activation of immune responses in plasma. Metabolomic analyses demonstrated significant upregulation of tryptophan metabolism in plasma and pyrimidine metabolism in BALF. Several biomarkers linked to host immune responses and viral replication were correlated with increased mortality. Finally, our analysis presented that distinct host protein expression and metabolic alterations in different sample types from patients with CMV reactivation may contribute to poor prognosis. These findings provide new insights into the impact of CMV reactivation in ARDS patients. |
| HostingRepository | iProX |
| AnnounceDate | 2025-10-09 |
| AnnouncementXML | Submission_2025-10-09_02:03:08.105.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jieqiong Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-09 02:02:48 | ID requested | |
| ⏵ 1 | 2025-10-09 02:03:08 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ARDS, CMV reactivation, Multi-omics |
Contact List
| Jieqiong Li | |
|---|---|
| contact affiliation | Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University |
| contact email | jieqiongli2010@163.com |
| lab head | |
| Jieqiong Li | |
| contact affiliation | Medical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University |
| contact email | jieqiongli2010@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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