PXD069217

PXD069217 is an original dataset announced via ProteomeXchange.

Title	Molecular features of human pathological Tau distinguish tauopathy-associated dementias (secondary cohort FLEXITau)
Description	In Alzheimer’s disease (AD), pathological Tau protein shows a progressive accumulation of post-translational modifications (PTMs), reflecting disease severity, progression, and prion-like activity. While many neurodegenerative diseases with dementia display Tau aggregates, the pathological proteoforms of Tau protein from each disease type remain unknown. Here, using quantitative mass spectrometry-based proteomics methods, deep characterization of pathological Tau protein isolated from the brains of 203 human subjects with AD, familial AD (fAD), chronic traumatic encephalopathy (CTE), corticobasal degeneration (CBD), Pick’s disease (PiD), progressive supranuclear palsy (PSP), dementia with Lewy bodies - symptomatic control (DLB), and healthy controls (CTRL) is performed. Unsupervised data analyses and supervised machine learning identify distinct molecular features of pathological Tau for each disease, enabling molecular disease stratification. This study identifies potential disease-specific biomarkers and therapeutic targets for tauopathies and provides critical pharmacokinetics data for therapeutic and disease mechanism studies.
HostingRepository	PRIDE
AnnounceDate	2026-02-19
AnnouncementXML	Submission_2026-02-19_01:48:06.052.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christoph Schlaffner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	ubiquitinylated lysine; methylated residue; phosphorylated residue; acetylated residue; L-citrulline
Instrument	Q TRAP

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-08 14:22:24	ID requested
⏵ 1	2026-02-19 01:48:06	announced

10.1016/J.CELL.2025.12.036;

submitter keyword: Neurodegeneration

Post-translational modification

proteolytic cleavage

clinical diagnosis

classification

Human Tau

SRM

Proteopathy

Protein aggregation

Judith A. Steen
contact affiliation	Department of Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
contact email	judith.steen@childrens.harvard.edu
lab head
Christoph Schlaffner
contact affiliation	Boston Children's Hospital; Harvard Medical School
contact email	christoph.schlaffner@childrens.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD069217

PRIDE project URI

• PRIDE
  1. PXD069217
     1. Label: PRIDE project
     2. Name: Molecular features of human pathological Tau distinguish tauopathy-associated dementias (secondary cohort FLEXITau)