PXD069194 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren’s disease: metabolic labelling and proteomics analysis of Dupuytren’s cord, nodule and normal palmar fascia controls (C4PR_LIV) |
| Description | Dupuytren’s disease is a fibroproliferative disorder of the palmer fascia characterized by flexion contractures in the hand. Dupuytren’s can be treated surgically but disease recurrence rates are high, potentially due to a continual production of matrisomal proteins. Metabolic labelling and proteomics were used to determine the differences in the new synthesis and composition of matrisomal proteins between Dupuytren’s tissue and normal palmar fascia. Dupuytren’s tissue actively synthesised type I collagen, fibronectin, matrix metalloproteinases-2 and -3 (MMP2, MMP3) and Tissue Inhibitor of Metalloproteinases 2 (TIMP2). Both tissues actively synthesized Insulin-Like Growth Factor Binding Protein 7 (IGFBP7). Label-free analysis implicated the TGFβ pathway in the matrisomal profile of Dupuytren’s tissue. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-17 |
| AnnouncementXML | Submission_2026-03-17_07:21:24.966.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD069194 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Philip Brownridge |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-08 02:21:58 | ID requested | |
| 1 | 2026-03-16 04:20:24 | announced | |
| ⏵ 2 | 2026-03-17 07:21:25 | announced | 2026-03-17: Updated project metadata. |
Publication List
| Cooper G, Gumbs JA, Alkharabsheh S, Lee KJ, Carter A, Coleman H, O'Heneghan-Yates NS, Ijaz R, Beamish E, Menezes LA, Liloglou T, Clegg PD, Canty-Laird EG, 1 signalling from collagen protein synthesis in Dupuytren's disease. J Pathol, 268(4):383-397(2026) [pubmed] |
| 10.1002/path.70020; |
| 10.6019/PXD069194; |
Keyword List
| submitter keyword: Dupuytren’s disease, fibroblasts |
Contact List
| Dr Elizabeth Laird |
|---|
| contact affiliation | Department of Musculoskeletal and Ageing Science Institute of Life Course and Medical Sciences University of Liverpool, UK |
| contact email | eglaird@liverpool.ac.uk |
| lab head | |
| Philip Brownridge |
|---|
| contact affiliation | University of Liverpool |
| contact email | philipjb@liv.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD069194 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069194
- Label: PRIDE project
- Name: Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren’s disease: metabolic labelling and proteomics analysis of Dupuytren’s cord, nodule and normal palmar fascia controls (C4PR_LIV)
