PXD069171 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Characterization of Mast2 Kinase Defines Structural Features, Regulation, and Substrates |
| Description | The mammalian microtubule-associated serine/threonine (MAST) kinases are a highly conserved subfamily of AGC kinases that are implicated as therapeutic targets for cancer and diabetes. However, the activity, regulation, and substrates of MAST kinases are poorly understood. Stable 18O-ATP labeled kinase assay linked phospho-proteomics (SIKALIP) identifies a collection of putative Mast2 substrate. Our results develop a biochemical profile of the MAST Kinases, provide insight into their regulatory mechanisms, and begin to identify the cellular functionof MAST2. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-04_16:11:04.009.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD069171 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Michael Lemke Lemke |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-10-06 12:05:54 | ID requested | |
| ⏵ 1 | 2026-01-04 16:11:05 | announced | |
Publication List
| 10.1016/j.jbc.2025.110922; |
| Lemke MC, Chen M, Jang SS, Rader MT, Avala NR, Bauchle CJ, Pluguez R, Miller CJ, Butler JD, Hargett SR, Lank DS, Seltzer BD, Stornetta DS, Fu Z, Hsu KL, Harris TE, Characterization of Mast2 kinase defines structural features, regulation, and substrates. J Biol Chem, 301(12):110922(2025) [pubmed] |
| 10.6019/PXD069171; |
Keyword List
| submitter keyword: Human, MAST2, SIKALIP |
Contact List
| Thurl Eugene |
|---|
| contact affiliation | Pharmacology, Harris Lab, Univeristy of Virginia, U.S.A. |
| contact email | teh3c@virginia.edu |
| lab head | |
| Michael Lemke Lemke |
|---|
| contact affiliation | UVA |
| contact email | lemkem0@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD069171
- Label: PRIDE project
- Name: Characterization of Mast2 Kinase Defines Structural Features, Regulation, and Substrates
