⮝ Full datasets listing
PXD069137
PXD069137 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Reconnecting Vagus Nerve to the Heart through Nerve Conduit Preserves Cardiac Function in a Minipig Model of Right Cardiac Vagotomy |
| Description | The right vagus nerve (RVN) plays a crucial role in maintaining cardiac homeostasis, and its intrathoracic resection leads to postoperative cardiac complications. Developing effective method to repair the RVN after surgical transection at the heart level is a critical unmet clinical need. Here we show that early reconnection of the RVN to the heart promoted by implantable Chitosan/Poly-e-caprolactone cuff-like nerve guidance conduit (ChiPCL. C-NGC) significantly preserves cardiac mechanical function in minipigs subjected to right cardiac vagotomy (RVT). Animals that were randomly treated with ChiPCL. C-NGC showed improved global circumferential, longitudinal, and radial strain, along with reduced diastolic dyssynchrony. Histopathology revealed 20% viable vagal fascicles, normalized levels of myocardial parasympathetic fibers, oxidative stress- and aging-related markers, and prevented interstitial myocardial fibrosis in treated group. Our findings suggest that preserving a limited number of RVN fascicles and their neurofilaments prevents early cardiac remodeling by lowering oxidative stress-mediated premature senescence of cardiac cells. Reconnecting the RVN to the heart via ChiPCL C-NGC presents a potential therapeutic strategy to prevent RVT-induced heart failure following thoracic surgery or heart and lung transplantation |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-02 |
| AnnouncementXML | Submission_2025-12-02_06:19:12.961.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Leibniz FLI Proteomics |
| SpeciesList | scientific name: Sus scrofa; common name: pig; NCBI TaxID: 9823; |
| ModificationList | Oxidation; Acetyl; Carbamidomethyl |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-10-05 06:35:31 | ID requested | |
| ⏵ 1 | 2025-12-02 06:19:13 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Vagus Nerve, Vagotomy, Implatation, Aging markers, Minipigs, DatasetType:Proteomics |
Contact List
| Alessandro Cellerino | |
|---|---|
| contact affiliation | Leibniz Institute on Aging, Beutenbergstr. 11, 07745 Jena |
| contact email | Alessandro.Cellerino@leibniz-fli.de |
| lab head | |
| Leibniz FLI Proteomics | |
| contact affiliation | Leibniz FLI |
| contact email | proteomics@leibniz-fli.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099384/ |
