PXD068982

PXD068982 is an original dataset announced via ProteomeXchange.

Title	Advancing Plasma Proteomics for the Discovery of Ovarian Cancer Biomarkers
Description	The development of ultrasensitive proteomic methods for the detection of proteins — potential tumor biomarkers — remains one of the key challenges in modern biomedicine. Based on data obtained using high-sensitivity technologies and the integration of proteomic and metabolomic layers of genome-encoded information, an expanded list of proteins associated with ovarian cancer progression has been compiled. A panel of ovarian cancer–specific markers, previously unreported in the scientific literature, has been identified. A total of 371 proteins were found to be potentially involved in the pathological process, with 33% detected exclusively by ultrasensitive methods, and 26% discovered through metabolomic associations. Among these, 6% correspond to proteins already recognized as ovarian cancer–specific. Nine potential biomarkers are discovered for the first time, including immunoglobulin variable region proteins (IGLV7-46, IGHV3-15, IGLV2-18, IGHV1-2), as well as ATRN, CPN1, APOF, TGM3, and CRNN, which participate in diverse biological processes such as cellular transport, enzymatic activity, lipid metabolism, and the maintenance of tissue structural integrity. The identified biomarkers are present in blood at concentrations ranging from 10⁻¹² to 10⁻⁶ mol/L. The proposed approach overcomes the sensitivity limitations of conventional proteomic methods and may be adapted for the discovery of candidate markers in other multifactorial diseases.
HostingRepository	PRIDE
AnnounceDate	2025-10-07
AnnouncementXML	Submission_2025-10-06_17:06:29.403.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gordeeva Arina
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-29 22:08:56	ID requested
⏵ 1	2025-10-06 17:06:29	announced

Dataset with its publication pending

ProteomeXchange project tag: Cancer (B/D-HPP), Human Proteome Project

submitter keyword: DDA-Shotgun proteomics, early diagnosis, metabolomics,ovarian cancer, personalized medicine, PMconv, multi-omics analysis, biomarkers, molecular mechanisms, LC-MS/MS, Selected Reaction Monitoring (SRM), AFM-assisted DDA-Shotgun LC-MS/MS

Arina Gordeeva
contact affiliation	IBMC
contact email	arina.atom@gmail.com
lab head
Gordeeva Arina
contact affiliation	researcher
contact email	arina.atom@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD068982

PRIDE project URI

• PRIDE
  1. PXD068982
     1. Label: PRIDE project
     2. Name: Advancing Plasma Proteomics for the Discovery of Ovarian Cancer Biomarkers